Pug Dog Encephalitis

Approximately 1.2% of Pug dogs die of necrotizing meningoencephalitis (NME), also known as Pug dog encephalitis (PDE).

NME is an inflammatory disease of the central nervous system that is usually progressive and fatal. Symptoms of NME include seizures, depression, ataxia, abnormal gait and blindness

This disease is not fully understood and it is believed that environmental factors or other genetic influences can also contribute to whether a dog becomes affected. Since other factors can influence whether a dog becomes affected by this condition, unlike most other DNA tests, this test evaluates a dog’s risk of developing the disease, rather than giving a definitive result.

Current research suggests that 12.5% of dogs that have two copies of the PDE gene variant will develop PDE.

Possible Test Results :

  • Clear (Minimal Risk)
  • Single Carrier (Minimal Risk)
  • Double Carrier (Increased Risk)
  • Hereditary Clear (Minimal Risk)
  • Hereditary Single Carrier (Minimal Risk)
  • Hereditary Double Carrier (Increased Risk)
More PDE (NME) Information (opens a new window)

Pug Dog Encephalitis is a recommended test for the following breeds :

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