Hyperuricosuria

Overview

Hyperuricosuria, which is also known as urate stone disorder, is an autosomal recessive inherited condition which can affect any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier.

Dogs with two copies of the SLC2A9 gene (one inherited from their mother and one inherited from their father) are predisposed to higher levels of uric acid in their urine.

Characteristics and Symptoms

The increased levels of uric acid in urine can lead to crystals and stone structures forming in the urinary tract. These can cause infections, blood in the urine and blockage of the urethra.

Prevention

There is a DNA test for the SLC2A9 gene associated with Hyperuricosuria.

Possible Test Results :

• Clear
• Carrier
• Affected
• Hereditary Clear
• Hereditary Carrier
• Hereditary Affected

Hyperuricosuria is a mandatory test for the following breeds :

• Large Munsterlander
• Russian Black Terrier

Hyperuricosuria is a recommended test for the following breeds :

• Bulldog
• Dalmatian
• French Bulldog
• Hungarian Wirehaired Vizsla

Hyperuricosuria is an optional test for the following breeds :

• Australian Shepherd
• Miniature American Shepherd