Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Overview

MCADD is caused by a fault in the gene that provides the instructions to make an enzyme called medium-chain acyl-CoA dehydrogenase (MCAD). This genetic fault causes the enzyme to either not work properly or be missing entirely, which means the body cannot fully break down fat to release energy.

Characteristics and Symptoms

With an early diagnosis, MCADD can be managed successfully by diet, a simple DNA test can save your dog’s life.

Signs and symptoms to watch out for our seizures, lethargy, episodes of illness (e.g. vomiting), unsteady gait, loss of appetite, low blood sugar, change in behaviour, respiratory distress, recurrent infections and neurological symptoms.

Prevention

DNA testing to see if your dog is clear, a carrier or affected by this condition. Only breeding from dogs that will result in puppies that are not affected by the condition.

Gene Tested : MCADD

Possible Test Results :

  • Clear
  • Carrier
  • Affected
  • Hereditary Clear
  • Hereditary Carrier
  • Hereditary Affected
More MCADD Information (opens a new window)