L-2-Hydroxyglutaric Aciduria

L-2-HGA (L-2-hydroxyglutaric aciduria) in Staffordshire Bull Terriers is a neurometabolic disorder characterised by elevated levels of L-2-hydroxyglutaric acid in urine, plasma and cerebrospinal fluid.

L-2-HGA affects the central nervous system, with clinical signs usually apparent between 6 months and one year (although they can appear later). Symptoms include epileptic seizures, "wobbly" gait, tremors, muscle stiffness as a result of exercise or excitement and altered behaviour.

Possible Test Results :

  • Clear
  • Carrier
  • Affected
  • Hereditary Clear
  • Hereditary Carrier
  • Hereditary Affected
More L-2-HGA Information (opens a new window)

L-2-Hydroxyglutaric Aciduria is a mandatory test for the following breeds :

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