Protein Losing Nephropathy

Protein Losing Nephropathy (PLN) is a condition in which plasma protein is lost to excess in the kidney.

SCWTs affected with PLN have damaged glomeruli because the holes in the sieve (basement membrane) are too large and allow more than waste to pass through.

Dogs with one or two copies of this mutation are at risk for developing PLN, although dogs with two copies have a much higher incidence of disease. This mutation is incompletely penetrant, meaning that other genetic and environmental factors contribute to the development of this disease.

Possible Test Results :

  • Clear
  • Single Carrier - At Risk
  • Double Carrier - At Risk
  • Hereditary Clear
  • Hereditary Single Carrier - At Risk
  • Hereditary Double Carrier - At Risk
More PLN Information (opens a new window)

Protein Losing Nephropathy is a recommended test for the following breeds :

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